SCLRCSCLRC

Improving Diagnostic and Treatment Outcomes for Cholestatic Liver Diseases and Pruritus

Course Overview

Cholestatic liver disease causes liver damage and fibrosis owing to bile stasis. It is represented by primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). The pathogenesis of the disease is still unclear, although autoimmune mechanisms have been postulated and partially elucidated. Although the disease may progress slowly with only mild liver dysfunction, it may advance to liver cirrhosis or liver failure. People living with PBC are frequently symptomatic, experiencing a quality-of-life burden dominated by fatigue, itch, abdominal pain, and sicca complex.

As a medical treatment, ursodeoxycholic acid is widely used for PBC and has proved to be very effective against disease progression in cases of PBC. But new treatments are now available or in late-stage development, offering options in addition to Urso.

The seminar will explore the general natural history of PBC and PSC and provide information on the latest drug therapies currently available as well as those under investigation. A special section will focus on the frequent complaint of itching and will focus on the management of Cholestatic Pruritus.



Topics to be addressed in this seminar include:

  • Discovery and natural history of the Primary Biliary Cholangitis, including the disease’s name change
  • Rate of Disease progression and why there is such variation
  • Prevalence and growth PBC in women and in men
  • The three prominent forms of PBC: How are they alike and how do they differ
  • The risk of liver failure and death increases as PBC progresses
  • Managing Pruritis in your PBC patients
  • Therapeutic agents available in the US for those with PBC and promising clinical trials
  • The new and emerging therapies for Primary Biliary Cholangitis – Methods of action and potential benefits
  • PSC diagnosis, natural history, clinical course
  • PSC treatment with UDCA and other treatments in development
  • What are the major differences between PBC and PSC
  • Take-home lessons and Proactive next steps


Dates and Locations



Check back after February 10th for dates and locations.

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A web-based, self-paced version of this seminar is also available. Go to the Registration/Information button, then scroll to the bottom of the page to register for the Enduring Material.

Registration Fees: There is no charge to participate in these programs, but pre-registration is required.

This program has been developed for:

Gastroenterologists
Internists
Family Physicians
Advanced-Practice Providers and Nurse Specialists
Clinical Pharmacists
Psychologists and Clinical Social Workers

For more information:

This course is supported in part by an educational grant from CymaBay, Intercept and Mirum in accordance with ACCME accreditation Standards of Commercial Support.




Designation Statements

AANP accepts Category I credit from AMA PRA Category 1 Credit(s)™ organizations accredited by ACCME.

Go to the Registration/Information button, then scroll to the bottom of the page to register for the Enduring Material.

Physicians Assistants - AAPA accepts Category I credit from AMA PRA Category 1 Credit(s)™ organizations accredited by ACCME.



For the Enduring Material: Go to the Registration/Information button, then scroll to the bottom of the page to register and access the course.

For Course or Content Information: Please contact SCLRC at cme@scliver.com or at (253) 432-4023

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